R-4-Boc-piperazine-2-carboxylic acid - Names and Identifiers
Name | 4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID
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Synonyms | B35611 (4-N-BOC)PIPERAZINE(2R) COOH R-4-Boc-piperazine-2-carboxylic acid 4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID (S)-4-Boc-2-piperazine carboxylic acid (R)-4-BOC-PIPERAZINE-2-CARBOXYLIC ACID (R)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID (R)-PIPERAZINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER (R)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID (2R)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (2S)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid 1,3-Piperazinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (3S)- (2S)-4-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperazinecarboxylic acid
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CAS | 192330-11-3
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InChI | InChI=1/C10H18N2O4/c1-10(2,3)16-9(15)12-5-4-11-7(6-12)8(13)14/h7,11H,4-6H2,1-3H3,(H,13,14)/t7-/m1/s1 |
R-4-Boc-piperazine-2-carboxylic acid - Physico-chemical Properties
Molecular Formula | C10H18N2O4
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Molar Mass | 230.26 |
Density | 1.193±0.06 g/cm3(Predicted) |
Melting Point | 231-239 ºC |
Boling Point | 371.8±37.0 °C(Predicted) |
Flash Point | 178.6°C |
Vapor Presure | 1.5E-06mmHg at 25°C |
pKa | 2.20±0.20(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | 1.495 |
R-4-Boc-piperazine-2-carboxylic acid - Risk and Safety
Hazard Symbols | Xi - Irritant
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Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin.
R43 - May cause sensitization by skin contact
R36 - Irritating to the eyes
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S36/37 - Wear suitable protective clothing and gloves.
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R-4-Boc-piperazine-2-carboxylic acid - Introduction
4-boc-piperine-2-(R)-CARBOXYLIC ACID, chemically named (R)-acid, is an organic compound containing a piperazine ring.
Nature:
The chemical formula of 4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID is C10H18N2O4, and the relative molecular mass is 238.26g/mol. It is a white crystalline solid, soluble in some organic solvents such as dichloromethane and ethanol. It has a melting point of about 126-128°C.
Use:
4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID is commonly used as an intermediate and protecting group in organic synthesis. It can be used to synthesize a variety of bioactive molecules, such as drugs, biological materials and pesticides. Because of its stereoselectivity, it can be used as a precursor of chiral catalyst for catalytic asymmetric synthesis.
Method:
4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID can be prepared by reacting piperazine with (Boc)2O under basic conditions. Piperazine is first dissolved in acetonitrile or methanol, a base catalyst such as triethylamine is added, (Boc)2O is added, and after completion of the reaction, hydrolysis acidification is carried out to obtain the target product.
Safety Information:
4-BOC-PIPERAZINE-2-(R)-carboxy ACID is generally low in toxicity and irritation, but it still needs to be operated according to laboratory standards. Contact with oxidizing agents, strong acids or strong bases should be avoided during handling and storage. Avoid direct contact with skin and eyes and wear appropriate personal protective equipment when using. If taken by mistake or inhaled by mistake, seek medical attention immediately.
Last Update:2024-04-09 21:04:16